May 27, 2023 | Diabetes Institute, Meetings
19th IDS Congress May 23–27, 2023 Paris, France Organized by Roberto Mallone & David Klatzmann
May 20, 2023 | Diabetes Institute, Insulin signaling, glucose sensing and glucotoxicity, Publications
Abstract Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). Hepatic metabolism of carbohydrates into...
Apr 20, 2023 | Diabetes Institute, Publications, T-cell tolerance, biomarkers and therapies in type 1 diabetes
A perplexing feature of type 1 diabetes (T1D) is that the immune system destroys pancreatic β-cells but not neighbouring α-cells, even though both β-cells and α-cells are dysfunctional. Dysfunction, however, progresses to death only for β-cells. Recent findings...
Apr 20, 2023 | Diabetes Institute, Publications, Regulation of Glycemia by Central Nervous System
Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice Abstract Innate immune mediators of pathogen clearance, including the secreted C-type lectins REG3 of the antimicrobial peptide (AMP) family, are known to be...
