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Tryptophan metabolism promotes immune evasion in human pancreatic β cells

Tryptophan metabolism promotes immune evasion in human pancreatic β cells

Nov 12, 2023 | Diabetes Institute, Functional pancreatic beta cell mass in rodent and human, Publications, Research, T-cell tolerance, biomarkers and therapies in type 1 diabetes

A collaborative work between the teams of R Mallone and R Scharfmann leaded by L Rachdi indicate that TRP could induce immune tolerance to β cells by promoting their immune evasion through HLA-I downregulation and PD-L1 upregulation.  
Serotonergic neurons are involved in the counter-regulatoryresponse to hypoglycemia

Serotonergic neurons are involved in the counter-regulatoryresponse to hypoglycemia

Nov 12, 2023 | Diabetes Institute, Publications, Regulation of Glycemia by Central Nervous System, Research

Christophe Magnan and Céline Cruciani-Guglielmacci in collaboration with the team of Xavier Fioramonti highlight a new neuronal network involved in the regulation of the counter-regulatory response  In particular, this study shows that DR 5-HT neurons detect...
New review from IMMEDIAB

New review from IMMEDIAB

Nov 12, 2023 | Immunity and Metabolism of Diabetes, Publications, Research

Here, we propose that a significant proportion of individuals may harbor an immune profile that renders them susceptible to developing T2D. We note the heterogeneity of circulating monocytes and tissue macrophages in organs that are key to metabolic disorders such as...
6th Symposium of the French Network on Monocytes-Macrophages – SoMM2023 –

6th Symposium of the French Network on Monocytes-Macrophages – SoMM2023 –

Oct 24, 2023 | Diabetes Institute, Immunity and Metabolism of Diabetes, Seminar

This event is organized by the  Macrophage Club Îles-de-France (MCI), with support from the National Macrophage Club Community (MaCRO), with the goal of bringing together experts in France working on the biology of monocytes and macrophages.
Symposium Institut Cochin “Why sex matters … in health and disease”

Symposium Institut Cochin “Why sex matters … in health and disease”

Oct 17, 2023 | Diabetes Institute, Seminar

L’IHM du Diabète vous invite à sa demi-journée scientifique sur la thématique du « Dialogue inter-organes dans le diabète » le 4 Juillet 2023 de 9h à 13h, Amphithéâtre 3 Site Necker, 160 rue de Vaugirard, 75015 Paris Lien vers le formulaire d’inscription : ...
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